HETEROZYGOTE EXCESS IN SMALL POPULATIONS AND THE HETEROZYGOTE-EXCESS EFFECTIVE POPULATION SIZE
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چکیده
منابع مشابه
Testing heterozygote excess and deficiency.
Currently used tests of Hardy-Weinberg proportions do not take into account the nature of the alternative hypothesis, which is generally a heterozygote deficiency. Different exact tests, appropriate for small sample size and large number of alleles, are proposed in this perspective, and their properties are evaluated by power comparisons. Some tests are found to be close to optimal for the dete...
متن کاملOn the potential for estimating the effective number of breeders from heterozygote-excess in progeny.
The important parameter of effective population size is rarely estimable directly from demographic data. Indirect estimates of effective population size may be made from genetic data such as temporal variation of allelic frequencies or linkage disequilibrium in cohorts. We suggest here that an indirect estimate of the effective number of breeders might be based on the excess of heterozygosity e...
متن کاملEstimating the effective number of breeders from heterozygote excess in progeny.
The heterozygote-excess method is a recently published method for estimating the effective population size (Ne). It is based on the following principle: When the effective number of breeders (Neb) in a population is small, the allele frequencies will (by chance) be different in males and females, which causes an excess of heterozygotes in the progeny with respect to Hardy-Weinberg equilibrium e...
متن کاملHeterozygote excess is repeatedly observed in females at the BRCA2 locus N372H.
E vidence of genotype specific selection at the BRCA2 polymorphism N372H was originally reported by Healey et al. These workers found significant evidence of a heterozygous excess in women control samples when studying the polymorphism for breast cancer association. They then genotyped a large series of newborn boys and girls to examine if this effect was also seen at birth. The newborn girls w...
متن کاملHeterozygote Detection
saemia in a British hospital, with emphasis on heterozygote detection. Results are reported of a screening programme for galactosaemia covering a period of 2A years and 6415 births. The gene frequency for galactosaemia estimated from the data of the screening programme was 0-002. This conflicted with the known livebirth incidence of at least 1: 50,000 during this same period. 2 of the 4 galacto...
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ژورنال
عنوان ژورنال: Evolution
سال: 2004
ISSN: 0014-3820,1558-5646
DOI: 10.1111/j.0014-3820.2004.tb00477.x